2017 Fall Edition                                                                                     http://research.dental.ufl.edu/

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Life in the Swamp begins now...

Faculty and Students in the News

 

Students Complete

 Summer Research Program

James Jang, Geena Addison Valdes, Catherine Baitinger, Miseanne Tang, Giovanna Bermudez Quiroz, Blake Crosby and Victor Chan ended the program successfully, with outstanding presentations and a lunch served to honor their remarkable 10 week journey. 

Special thanks to the mentors: Drs. Toth, Diamond, Lemos, Abranches, Katz, Shaddox and Burne. Special thanks to Denise Webb, who assisted in the organization of the program and making this all possible.

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Dr. Joseph Katz, professor of oral medicine, Department of Oral and Maxillofacial Diagnostic Sciences mentored Catherine Baitinger, a D.M.D. candidate during this year's 2017 Summer Research Program.

Their study, in collaboration with Dr. Jan Moreb, mone marrow unit at UF Health and Dr. Caudle, Department of Oral Surgery evaluated the levels of advanced glycation end products (AGEs) in the saliva of patients diagnosed with multiple myeloma, or MM, and awaiting bone marrow transplantation.

Multiple myeloma, a form of cancer of the bone marrow affects the production of plasma cells and different immunoglobulins, which may affect the bones causing significant morbidity for the patient.

Currently, there are no good biomarkers for disease progression of the bone; when CT and X-ray imaging are used the disease has already spread to involve the bone.

Advanced glycation end products are toxic compounds present in tissues and body fluids in states of inflammation and increased oxidative stress. New evidence suggests a relationship between oxidative stress and hematological malignancies such as chronic lymphocytic leukemia, Hodgkin's lymphoma, and MM.

Accumulation of AGEs in bone contributes to disturbed bone remodeling, deterioration of bone tissue quality, bone density, and mineralization. Their study found that AGEs were significantly higher in the plasma of MM patients with bone lesions compared to those without lytic bone lesions.

A recent study published in the journal, Leukemia and Lymphoma, demonstrated that the levels of AGEs are increased in the saliva of myeloma patients with bone lesions compared to non-lesions. This data may provide a potential marker for bone involvement in MM and may function as a potential target for the treatment of the disease, by blocking AGEs or their receptor. This study further emphasizes the increasing importance of saliva as a “liquid biopsy” for systemic markers of diseases.

Catherine, originally from New Jersey, moved to Gainesville to complete her undergraduate degree at UF in Human Nutrition and Food Science. Catherine’s research interests include oral medicine and pathology. She enjoys spending her free time volunteering in the dental student clinics. During undergraduate studies, Catherine was involved in the Pre-Dental American Student Dental Association and UF’s Pre-Dental Society.

 

Office of Research Updates

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Meet Zina Zander

Zina Zander, research administration assistant, joined the Office of Research in July. She primarily focuses on proposal preparation, pre-award activity and data collecting / reporting. Zina transferred from the College of Veterinary Medicine where she gained experience in research administration. Zina also volunteered with the veterinary medicine Infectious Diseases and Pathology labs. If you are planning to submit a proposal in the near future, please contact either Zina or Christi Mason. 

• Beverly Davies, Research Administrator II, retired August 16th.  

• New financial reports are being distributed to Principle Investigators. Ronda Breton, grant accounting manager, has worked with UF Enterprise Reporting to develop comprehensive, yet streamlined reports. 

• Due to changes in staff and the introduction of new business processes (IE, UFirst) the office is reviewing the current organizational structure. We are soliciting feedback and hope to finds ways to improve our service to faculty and staff.

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Improvements to the Institutional Animal Care and Use Committee (IACUC)

& Animal Care Services (ACS)

In August, representatives from the IACUC and ACS met with college researchers to discuss how these units are working to improve services. The meeting was led by Dr. Mike Katovich, director for UF's IACUC, Mr. Michael Mahoney, director of research operations, UF Division of Sponsored Programs, and Dr. Irene Cooke, acting executive director, UF Animal Care Services. Dr. Katovich stated that a task force was established to review current procedures and make recommendations for improvements.  

Dr. John Neubert from orthodontics represented UFCD as a task force member. Changes include: streamlining the submission process, elimination of annual reviews (unless required by a sponsor), simplification of the drug policy, and shortening the protocol review period. The IACUC continues to review existing polices, and work to enhance the IACUC website.   

Dr. Cooke indicated that improving the work environment for the ACS staff leads to better services, communications and fruitful partnerships with peer units. She encouraged faculty to discuss
their research activities with the ACS staff. 

Both areas are now collecting data and establishing metrics to track improvements to service. Faculty and staff are encouraged to provide feedback at any time.  

ACS Dentistry Power Point Presentation

IACUC Improvements

 

NIH News

News from NIH Extramural Nexus
Dr. Mike Lauer, NIH deputy director for extramural research discusses NIH’s initiative to improve the quality and transparency in human subject and/or clinical trial research. The agency has
developed a simple four question survey to help investigators define clinical research.  More….

Upcoming NIH Application Due Dates

General Information

Grant applications and associated documents (e.g., reference letters) are due by 5:00 PM local time of application organization on the specified due date.

Activity Codes                                Program Description                                  Cycle III Due Date

R01                                                   Research Grants                                                    5-Oct

R03, R21                        Other Research Grants & Cooperative Agreements           16-Oct

Renewals, Resubmissions, Revisions

R01                                                    Research Grants                                                   5-Nov

R03, R21                        Other Research Grants & Cooperative Agreements           16-Nov

F Series Fellowships      Individual Natl. Research Service Awards (Standard)          8-Dec

(including F31 Diversity-NOT-OD-17-029) 

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Review and Award

                                                           Cycle III

• Application Due Dates                 September 25-January 7

• Scientific Merit Review                 February-March

• Advisory Council Round               May

• Earliest Project Start Date            July

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NOTES:

The actual date of the Advisory Council may occur in the month before or after the month listed. For example, some ICs may actually hold the January Advisory Council meeting in February or the October Advisory Council meeting in September.

Awarding components may not always be able to honor the requested start date of an application.  Before incurring, any pre-award obligations or expenditures applicants should be aware of NIH policy governing pre-award costs prior to receiving a Notice of Award. See the NIH Grants Policy Statement. 

* Advisory Council Round for Cycle I applications (Cycle III for SBIR/STTR) may be August or October, and their earliest project start date may be September or December respectively.

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