Scott Harden

Scott W Harden, MS, DMD, PhD

Entered Joint-Degree Program: Fall 2012 as 4th year DMD student

Graduated program: Summer 2016 with a PhD in Neurobiology

Biography: Scott has a lifelong interest in the intersection of science, medicine, and technology. After completing a Master’s degree in molecular biology and microbiology from the University of Central Florida, Scott moved to Gainesville to begin dental school at the University of Florida. As a DMD-PhD student, Scott blended the academic and clinical training of an education in dental medicine with a scientific and technical education in the field of neuroscience. Scott’s research interests are focused on central and peripheral cellular neurophysiology, and his affinity for technology and engineering leads him to use new and emerging electrophysiological and optical devices to advance the field of biomedical research. Scott’s personal interests involve electrical engineering and computer programming, and when at home he can often be found building electrical devices and contributing to open-source hardware and software projects.


Thesis Advisor: Charles Jason Frazier, PhD

Publications

Tan Y, Singhal SM, Harden SW, Cahill KM, Nguyen DM, Colon-Perez LM, Sahagian TJ, Thinschmidt JS, de Kloet AD, Febo M, Frazier CJ, Krause EG. Oxytocin Receptors Are Expressed by Glutamatergic Prefrontal Cortical Neurons That Selectively Modulate Social Recognition. J Neurosci. 2019.24;39(17):3249-3263. PMID: 30804095.
Hernandez CM, Orsini CA, Labiste CC, Wheeler AR, Ten Eyck TW, Bruner MM, Sahagian TJ, Harden SW, Frazier CJ, Setlow B, Bizon JL. Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats. Elife. 2019. 24;8:e46174. PMID: 31017572.
Harden SW, Frazier CJ. Oxytocin depolarizes fast-spiking hilar interneurons and induces GABA release onto mossy cells of the rat dentate gyrus. Hippocampus. 2016. 26(9):1124-39. PMID:27068005.
Graves CL, Harden SW, LaPato M, Nelson M, Amador B, Sorenson H, Frazier CJ, Wallet SM. A method for high purity intestinal epithelial cell culture from adult human and murine tissues for the investigation of innate immune function. J Immunol Methods. 2014. 414:20-31. PMID: 25193428
Catalfamo DL, Calderon NL, Harden SW, Sorenson HL, Neiva KG, Wallet SM. Augmented LPS responsiveness in type 1 diabetes-derived osteoclasts. J Cell Physiol. 2013. 228(2):349-61. PMID: 22718269.
Mirescu SC, Harden SW. Photoplethysmography as a Potential Alternative to Electrocardiography for Recording Heart Rate Intervals Used in Variability Analysis. J Med Life. 2012. 5(Spec Issue):123-128. PMID: 31803299.
Lin M, Harden SW, Li L, Wurster RD, Cheng ZJ. Impairment of baroreflex control of heart rate in conscious transgenic mice of type 1 diabetes (OVE26). Auton Neurosci. 2010. 15;152(1-2):67-74. PMID: 19910264.
Gu H, Zhang ZH, Epstein PN, Li L, Harden SW, Wurster RD, Cheng ZJ. Impaired baroreflex control of renal sympathetic nerve activity in type 1 diabetic mice (OVE26). Neuroscience. 2009.16;161(1):78-85. PMID: 19303918.
Lin M, Ai J, Harden SW, Huang C, Li L, Wurster RD, Cheng ZJ. Impairment of baroreflex control of heart rate and structural changes of cardiac ganglia in conscious streptozotocin (STZ)-induced diabetic mice. Auton Neurosci. 2010. 24;155(1-2):39-48. PMID:20171940.
Yan B, Li L, Harden SW, Epstein PN, Wurster RD, Cheng ZJ. Diabetes induces neural degeneration in nucleus ambiguus (NA) and attenuates heart rate control in OVE26 mice. Exp Neurol. 2009. 220(1):34-43. PMID: 19615367.
Ai J, Wurster RD, Harden SW, Cheng ZJ. Vagal afferent innervation and remodeling in the aortic arch of young-adult fischer 344 rats following chronic intermittent hypoxia. Neuroscience. 2009. 1;164(2):658-66. PMID: 19580847.
Lin M, Chen QH, Wurster RD, Hatcher JT, Liu YQ, Li L, Harden SW, Cheng ZJ. Maternal diabetes increases small conductance Ca2+-activated K+ (SK) currents that alter action potential properties and excitability of cardiac motoneurons in the nucleus ambiguus. J Neurophysiol. 2010. 104(4):2125-38. PMID: 20668269.
Li L, Huang C, Ai J, Yan B, Gu H, Ma Z, Li AY, Xinyan S, Harden SW, Hatcher JT, Wurster RD, Cheng ZJ. Structural remodeling of vagal afferent innervation of aortic arch and nucleus ambiguus (NA) projections to cardiac ganglia in a transgenic mouse model of type 1 diabetes (OVE26). J Comp Neurol. 2010. 15;518(14):2771-93. PMID: 20506475.
Yan B, Li L, Harden SW, Gozal D, Lin Y, Wead WB, Wurster RD, Cheng ZJ. Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats. Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R299-308. PMID: 19020286.
Cirino TJ, Harden SW, McLaughlin JP, Frazier CJ. Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus. Journal of Neurophysiology. 2020. 123(4):1332-1341. PMID: 32101482
Pati D, Harden SW, Sheng W, Kelly KB, Kloet AD, Krause EG, Frazier CJ. Endogenous oxytocin inhibits hypothalamic CRH neurons following acute hypernatremia. Journal of Neuroendocrinology 2020. doi:10.1111/jne.12839 PMID: 32133707
Hernandez CM, Orsini CA, Labiste CC, Wheeler AR, Eyck TWT, Bruner MM, Sahagian TJ, Harden SW, Frazier CJ, Setlow B, Bizon JL. 2019. Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats. Elife 2019. doi: 10.7554 PMID: 31017572