Seung Jin (James) Jang

James Jang

Entered Joint-Degree Program: Summer 2017 as entering DMD student in the optional DMD Summer Research Program.

Biography:

James was born in South Korea, but grew up in Gainesville, Florida. He graduated Summa Cum Laude from the University of Florida where he majored in Interdisciplinary Biochemistry and Molecular Biology. Prior to joining the DMD/PhD program at UF, he worked in multiple laboratories at National Institutes of Health. First, he joined the lab of Dr. Lothar Hennighausen studying histone methylation catalyzed by MLL4 in mammary tissue during pregnancy. Afterwards, he worked in the lab of Dr. Adrian Wiestner assisting in IGHV sequencing in CLL patients, and later joined the lab of Dr. Swee Lay Thein, investigating the NETosis of Neutrophils in Sickle Cell Disease. During his time at NIH, he regularly attended NIDCR rounds and was inspired by NIDCR scientists and their research work. While not working in the lab, he served as the president of the Society of St. Vincent de Paul at his Catholic Church. Every fifth Saturday of the year, he and his friends from the church and NIH served lunch meals to over one hundred homeless people and provided dental supplies to homeless shelters in Washington D.C.

Currently, he has been working in Dr. Zsolt Toth’s laboratory as a DMD/PhD student, where he investigates the role of viral interferon regulatory factors in Kaposi’s sarcoma-associated herpesvirus infection of oral epithelial cells. He has been actively involved with the AADR National Student Research Group. While serving as the President of the UFCD Student Research Group, he strengthened the bridge between the students and the dental research faculty members by organizing multiple lunch and learn, dinner and learn events, and other meetings by working with various departments in UF College of Dentistry. By serving as the NSRG regional representative, he reached out to officers and faculty advisors in the schools in his region to ensure that Local Student Research Groups continue kept in touch with the National Student Research Group and be informed with the NSRG opportunities.

During his free time, he enjoys scuba diving in Florida springs and beaches, as well as camping and hiking in the Georgia mountains.

Publications

Golas JG, Jang SJ, Naik NG, Alonso JD, Papp B, and Toth Z. (2020) Comparative analysis of the viral interferon regulatory factors of KSHV for their requisite for virus production and inhibition of the type I interferon pathway. Virology, 2020 (541) p160-173 NIHMSID: NIHMS1548084.doi: 10.1016/j.virol.2019.12.011. (*equal contribution)
Papp B#, Motlagh N, Smindak RJ, Jang SJ, Sharma A, Alonso JD, and Toth Z# (2019) Genome-wide identification of direct RTA targets reveals key host factors for KSHV lytic reactivation. Journal of Virology, J Virol. 2018 Dec 12. pii: JVI.01978-18. doi: 10.1128/JVI.01978-18. [Epub ahead of print] PMID: 30541837 (#corresponding)
Yoo KH, Kang K, Feuermann Y, Jang SJ, Robinson GW, Hennighausen L. The STAT5-regulated miR-193b locus restrains mammary stem and progenitor cell activity and alveolar differentiation. Dev Biol. 2014; 395(2):245-54. PMID 25236432
Robinson GW, Kang K, Yoo KH, Tang Y, Zhu BM, Yamaji D, Colditz V, Jang SJ, Gronostajski RM, Hennighausen L. Coregulation of genetic programs by the transcription factors NFIB and STAT5. Mol Endocrinol. 2014; 28(5):758-67. PMID: 24678731
Feuermann Y, Kang K, Gavrilova O, Haetscher N, Jang SJ, Yoo KH, Jiang C, Gonzalez FJ, Robinson GW, Hennighausen L. MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse. RNA Biol. 2013; 10(12):1807-14. PMID: 24356587

Abstracts

Jang SJ, Alonso JD, Papp B, Toth Z. Revealing Critical Immunoregulatory Domains of vIRF1 for HHV8 oral infection. J Dent Res 99: Spec Iss A: Abstract 3320766, 2020, (www.iadr.org).
Jang SJ, Alonso JD, Glickman K, Papp B, Toth Z. Immunoregulatory Roles of the KSHV Viral Proteins during Oral Infection. J Dent Res 98: Spec Iss A: Abstract 3180877, 2019, (www.iadr.org).
Jang SJ, Papp B, Toth Z. Role of the KSHV vIRFs in viral replication and pathogenesis. J Dent Res 97: Spec Iss A: Abstract 2851566, 2018, (www.iadr.org).